Eric Devaney Lab - Research

Induced Pluripotent Stem Cells

Induced pluripotent stem cells are stem cells which can be generated directly from a patients own cells.

Figure 1. Fibroblasts reprogrammed to Induced Pluripotent Stem Cells

Induced pluripotent stem cells have the cellular phenotype of the stem cells which give rise to all the cells in the body.

Figure 2. Induced pluripotent stem cells stained for the stem cell markers Oct4, Nanog, and TRA-1-81.

Once a patients cells are reprogrammed to a pluripotent state, they can then be differentiated into a various tissues.
Movie 1. A beating sheet of patient specific engineered cardiac tissue.

One of the major goals of the Devaney lab is to use tissue engineering to generate implantable patches containing scaffolded autologous cardiovascular tissue into the right ventricular outflow tract, aorta, or pulmonary artery of patients with congenital heart disease. These potential applications of autologous engineered tissue will likely provide a safer and more effective replacement for the current standard of care; prosthetic valves and synthetic materials currently used in heart surgery.

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